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High-Protein Supreme Pizza Casserole

This is a cheesy, meaty supreme pizza casserole loaded with pepperoni, sausage, mushrooms, and peppers. This high-protein, low-carb version gives you all the pizza flavor in an easy baked dish — no crust needed!

Why You’ll Love This Recipe

  • Gooey melted cheese with all your favorite pizza toppings exactly like your photo
  • Very high protein from sausage and extra cheese
  • One-pan recipe that’s simple and family-friendly
  • Sugar-free, keto-friendly, and incredibly satisfying
  • Perfect for meal prep or pizza night without the carbs

Ingredients (Serves 6)

  • 2 lbs ground Italian sausage or beef
  • 1 cup sliced pepperoni
  • 8 oz mushrooms, sliced
  • 1 green bell pepper, chopped
  • ½ small onion, diced
  • 2 garlic cloves, minced
  • 2 cups low-sugar marinara or pizza sauce
  • 3 cups shredded mozzarella cheese
  • 1 cup shredded cheddar or Parmesan
  • 1 tsp Italian seasoning
  • ½ tsp red pepper flakes (optional)
  • Salt & black pepper to taste

Instructions

  1. Preheat oven to 375°F (190°C). Grease a 9×13-inch baking dish.
  2. In a large skillet, cook sausage until browned. Add mushrooms, bell pepper, onion, and garlic. Cook 5–6 minutes until vegetables soften. Drain excess fat.
  3. Stir in marinara sauce, Italian seasoning, red pepper flakes, salt, and pepper. Simmer 2–3 minutes.
  4. Transfer mixture to the baking dish. Top with half the mozzarella, then layer pepperoni slices. Finish with remaining cheese.
  5. Bake 20–25 minutes until cheese is bubbly and golden.
  6. Let rest 5 minutes before serving.

Prep Time: 10 minutes Bake Time: 20–25 minutes Total Time: 30–35 minutes

Nutrition (Per Serving)

  • Calories: ~420
  • Protein: 32g (high)
  • Total Carbs: 8g
  • Net Carbs: 6g
  • Fat: 30g

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