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High-Protein Pepperoni Pizza Casserole

High-Protein Pepperoni Pizza Casserole

This is cheesy high-protein pepperoni pizza casserole. Layers of seasoned ground beef, rich tomato sauce, melted mozzarella, and crispy pepperoni on top — a delicious low-carb pizza alternative the whole family will love!

Why You’ll Love This Recipe

  • Golden melted cheese and pepperoni topping
  • High protein from ground beef and cheese
  • One-dish easy dinner
  • Perfect for pizza cravings without the carbs
  • Low carb and sugar-free

Ingredients (Serves 6)

  • 1½ lbs lean ground beef
  • 1 small onion, diced
  • 2 cloves garlic, minced
  • 1½ cups sugar-free pizza sauce or marinara
  • 1 tsp Italian seasoning
  • ½ tsp dried oregano
  • Salt and black pepper to taste
  • 2 cups shredded mozzarella cheese
  • 20–25 slices pepperoni
  • Optional: ½ cup grated Parmesan
  • Fresh parsley or basil for garnish

Instructions

  1. Preheat oven to 375°F (190°C).
  2. In a large skillet over medium heat, cook ground beef and onion until beef is browned. Drain excess fat. Add garlic and cook 30 seconds more.
  3. Stir in pizza sauce, Italian seasoning, oregano, salt, and pepper. Simmer for 3–4 minutes.
  4. Transfer the meat mixture to a 9-inch or similar glass baking dish and spread evenly.
  5. Sprinkle mozzarella cheese evenly over the top. Arrange pepperoni slices in a single layer. Add Parmesan if using.
  6. Bake for 18–22 minutes until cheese is melted and bubbly and pepperoni is slightly crispy.
  7. Let rest 5 minutes, garnish with parsley if desired, and serve.

Prep Time: 10 minutes Cook Time: 25 minutes Total Time: 35 minutes

Nutrition (Per Serving)

  • Calories: ~380
  • Protein: 32g
  • Total Carbs: 6g
  • Net Carbs: 5g
  • Fat: 24g

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